Intrauterine insemination

Intrauterine insemination, also known as IUI, is one of the simplest and most common methods of assisted reproduction. It is a minimally invasive procedure, which can offer many couples the possibility to increase the chances of achieving pregnancy when the appropriate medical conditions are present.

The method can be performed either with the partner's sperm or with a donor sperm, depending on the history, needs and indications of each case. It can be an option for couples with mild fertility problems, for women with diabetic fallopian tubes, for cases where there is difficulty or inability to have sexual intercourse, as well as for women or couples who need donor sperm.
However, intrauterine insemination is not suitable for all cases. Its selection must be made after a careful evaluation, with realistic information and without cultivating unrealistic expectations.

What is Intrauterine insemination?

the intrauterine insemination It is a method in which the sperm is first subjected to a special laboratory treatment, in order to select the most mobile and appropriate spermatozoa.

The processed sample is then placed directly into the woman's womb, with the help of a very thin and soft catheter. In this way, the spermatozoa come closer to the fallopian tubes, where the fertilization of the egg can normally be done.

The procedure is short, simple and usually painless. It is carried out in a medical environment, without the need for anesthesia, and lasts a few minutes. Technically it looks like a simple gynecological examination, like the Pap test.

Insemination can be performed in either natural cycle either in a circle with Mild drug ovarian stimulation, depending on the woman's history, age, ovulation, sperm quality and overall evaluation of the couple.

In which cases is intrauterine insemination indicated?

Intrauterine insemination can be suggested in cases where there are specific indications and the chances of success are considered realistic.

Common indications are:

  • a mild disorder in the semen, such as reduced motility or concentration, but when the sample remains appropriate for the method,
  • Unexplained infertility, when the couple's basic control does not reveal a clear cause,
  • ovulation disorders, such as polycystic ovary syndrome, if ovulation can be achieved with appropriate drug support;
  • mild endometriosis, when there is no severe damage to the fallopian tubes or reproductive organs;
  • difficulty or inability to have sexual intercourse,
  • Cases where donor sperm is required.

IUI can also be a first therapeutic approach before more complex methods, such as IVF. Nevertheless, the decision must be made individually, as in some cases the immediate choice of another method may be more appropriate.

When is it Not recommended?

Although intrauterine insemination is a simple and safe procedure, it is not a solution for any form of infertility.

It is not usually recommended in cases such as:

  • blocked or severely damaged fallopian tubes,
  • severe male infertility factor,
  • severe hormonal disorders that do not respond to treatment,
  • important pathologies of the uterus or endometrium that prevent implantation,
  • Advanced reproductive age, when the chances of success with IUI are very low.

In these cases, a different therapeutic strategy may be needed. The role of the fertility specialist is to clearly explain which options have real meaning for the particular couple, avoiding unnecessary efforts, delays and false expectations.

What are the necessary conditions for IUI?

For intrauterine insemination attempts to make sense, some basic conditions must be met.

The first and most important is the Passability of the fallopian tubes. At least one fallopian tube must be open and functional so that the egg-to-viral encounter can take place.

Equally important is the existence of a sufficient number of moving sperm after laboratory processing of the sample. If the semen is severely disturbed, insemination may not be the appropriate method.

At the same time, the uterus and endometrium must have been checked. Pathological findings, such as polyps, submucosal fibroids or significant endometrial lesions, may reduce the chances of implantation and need treatment before trying.

The correct assessment before the IUI is decisive, because it helps the couple to know if the method has a real chance of success in their own case.

In what ways is it carried out?

Intrauterine insemination can be performed in two main ways: in a natural cycle or in a cycle with medicinal stimulation.

Natural intrauterine insemination

In natural intrauterine insemination, the procedure is done without the use of drugs to stimulate the ovaries. The woman's natural cycle is monitored by ultrasounds and, where necessary, by hormonal tests, in order to accurately determine the moment of ovulation.

Insemination is programmed at the appropriate time, just before or near ovulation, in order to increase the chances of the egg encountering the sperm.

Natural insemination may be suitable for women with a stable cycle and normal ovulation, for couples who wish to avoid taking medication, as well as for cases where donor sperm is used or there is difficulty in sexual intercourse.

Its advantage is that it is a milder approach, without a pharmaceutical burden. However, the chances of success depend on many factors, such as the age of the woman, the quality of the sperm and the overall history of the couple.

Intrauterine insemination with ovarian stimulation

In some cases, insemination is performed in a cycle with mild drug stimulation of the ovaries. The goal is to develop one or more mature follicles to increase the chances of conception.

Stimulation can be done with drugs such as clomiphene (in the form of a pill) or with gonadotropins, (in the form of subcutaneous injection) as the case may be. The development of the follicles is closely monitored by ultrasounds to control the response of the ovaries and prevent excessive stimulation.

When the follicles reach the appropriate size, a chorionic gonadotropin injection may be given to induce ovulation. Insemination is usually programmed about 36 hours later.

IUI with arousal can be applied in cases such as:

  • Polycystic ovary syndrome,
  • ovulation disorders,
  • unexplained infertility,
  • mild male agent,
  • Previous failed attempts at IUI physics.

The choice of drug stimulation must be done with caution, as it requires proper monitoring and individualization, in order to reduce the risk of multiple pregnancy or other complications.

How is the IUI process done step by step?

The process begins with monitoring the woman's cycle. Depending on whether it is a natural or stimulated cycle, the doctor monitors the development of the follicle or follicles by ultrasound and, if necessary, with hormonal tests.

On the day of insemination, the sperm sample is taken from the partner or a properly prepared donor sample is used. The sperm is processed in the laboratory to isolate the most mobile and quality sperm.

The processed sample is then placed inside the uterus with a thin catheter. The procedure is short, does not require anesthesia and the woman can usually return to her daily activities immediately.

After insemination, the doctor gives personalized instructions and sets the appropriate time for a pregnancy test.

Realistic expectations and success rates

The success of intrauterine insemination depends on many factors. An important role is played by the age of the woman, the quality of the sperm, the passability of the fallopian tubes, the existence or not of ovulation, the history of the couple and the cause of infertility.

For this reason, there is no general answer that applies to everyone. In some pairs, IUI can be a logical and effective first choice. In others, it may not offer substantial chances and need a different approach.

Responsible medical guidance is not based on the cultivation of expectations, but on honest information. The couple must know from the beginning what the method can offer, what are its limitations and when it is right to proceed to the next step.

Personalized care by Ioannis Sklavounos

Choosing the appropriate treatment in infertility requires experience, attention and proper judgment. It is not enough to apply a method because it is simple or widespread. What is important is to choose the right method for the right pair, at the right time.

The Obstetrician-Gynecologist Ioannis Sklavounou It has 10 years of training in England and specialization in reproductive medicine, infertility and fetal uterine medicine. And another 20 years of experience and handling of extremely difficult cases in Greece, handling cases with multiple failures from Greece and abroad. His many years of training in demanding medical environments abroad have provided him with substantial experience in dealing with complex and difficult cases.

In its approach, each pair is evaluated individually. The doctor personally deals with each case, spends time in detailed investigation, clearly explains the findings and plans the appropriate therapeutic strategy without haste and without discounting the quality of care.

His experience in dealing with demanding cases, combined with high success rates, are important elements of his medical course. At the same time, his philosophy is based on honesty and realism: he does not cultivate false expectations, but responsibly informs each couple about their real choices.

The goal is to provide scientifically documented, human and personalized care to every woman and every couple who wish to have a child.

If you are looking for specialized guidance for intrauterine insemination or any infertility issue, you can contact the doctor's office and schedule your appointment.

IVF

Bibliography

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    Intrauterine Insemination.
    Human Reproduction Update.
  6. Cohlen, B. J., et al.
    IUI: Review and Systematic Assessment of the Evidence That Supports Global Recommendations. Human Reproduction Update.
  7. Veltman-Verhulst, S. M., Cohlen, B. J., Hughes, E., Heineman, M. J.
    Intra-Uterine Insemination for Unexplained Subfertility.
    Cochrane Database of Systematic Reviews.
  8. World Health Organization — Who.
    Who Laboratory Manual for the Examination and Processing of Human Semen.
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    The International Glossary on Infertility and Fertility Care, 2017.
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Ioannis A. Sklavounos MD MSC DFFP
Obstetrician Surgeon Gynecologist
Specialists & Retrained in Great Britain
T.Senior Clinical Fellow – Liverpool Woman’s Hospital UK

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