Repeated IVF failures

Recurrent IVF failures are a particularly demanding and psychologically charged situation for couples seeking pregnancy through IVF.

In most cases where IVF fails, the cause is related to embryos. But when there is a repeated failure of implantation or recurrent miscarriages after embryoEhfeed with good quality embryos, Further investigation of the causes is required. It is a multifactorial problem, which may be related to genetic, anatomical, immunological, endocrinological or even environmental factors, necessitating an individualized approach and specialized medical care.

More specifically, the factors that affect the outcome of an IVF are the following:

  • – woman's age: It is the most important factor, as the gradual reduction of the ovarian reserve and the drop in egg quality are associated with lower rates of fertilization and an increased risk of chromosomal abnormalities in the embryos.
  • – Age Man – Sperm Quality: The biological age and genetic integrity of the sperm, particularly the presence of DNA segments, affect the fertilization capacity and are associated with increased rates of miscarriage.
  • – genetic factors: Chromosomal or other genetic abnormalities can affect the morphology and functionality of gametes. All this leads to implantation failure or early miscarriages.
  • – Environmental factors: Smoking, obesity, poor diet and exposure to toxic substances have a proven negative effect on the quality of both eggs and sperm.

At the same time, the experience of the embryologist and the technological capabilities of the laboratory are decisive factors for the selection of the most suitable gametes.

overall, IVF success results from a complex biological interaction and environmental factors. These factors shape the quality of gametes and, ultimately, the possibility of achieving pregnancy.

In our practice, taking into account factors such as your age and your medical history, we may recommend some of the following specialized tests:

Exams for the woman:

– Thromophilia test: Reveals a number of genetic or acquired factors that increase the likelihood of small blood clots forming. These clots can lead to failure of implantation or the abortion of the fetus, due to insufficient blood supply. Such problems can often be treated in a simple way, such as with aspirin or heparin.

– hormonal control: It can reveal small disturbances in the levels of hormones which, for example, are due to disturbances in the functioning of the thyroid. Such disorders may not affect general health, but affect the ability to achieve and maintain pregnancy.

– Hysterosalpingography: An examination that can reveal anatomical problems of the uterus or the concentration of fluid in the fallopian tubes (hydrosalpinx).

– Hysteroscopy: With the help of a small camera, a visual overview of the endometrium is done.

Exams for the man:

– Sperm DNA Segmentation Examination (Sperm Fragmentation Assessment). A high rate of segmentation appears to be associated with reduced implantation rates and increased miscarriage rates.

–imsi: Includes the selection of sperm using a high magnification microscope. It seems that this technique can help in cases of repeated failure of implantation or repeated miscarriages.

 

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Fertility & IVF Center in Maroussi

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